Molecular Formula | C31H28ClN7O2 |
Molar Mass | 566.05 |
Density | 1.379±0.06 g/cm3(Predicted) |
Solubility | DMSO: ≥ 39 mg/mL |
pKa | 13.06±0.70(Predicted) |
Storage Condition | -20℃ |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.767 ml | 8.833 ml | 17.666 ml |
5 mM | 0.353 ml | 1.767 ml | 3.533 ml |
10 mM | 0.177 ml | 0.883 ml | 1.767 ml |
5 mM | 0.035 ml | 0.177 ml | 0.353 ml |
biological activity | THZ2 is an analog of THZ1, a selective inhibitor of CDK7, and its IC50 value is 13.9 nM. THZ2 can effectively inhibit the clone formation and growth of TNBC cells, and its IC50 value is about 10 nM. |
target | TargetValue CDK7 (Cell-free say) 13.9 nM |
Target | Value |
CDK7 (Cell-free assay) | 13.9 nM |