Benzamide, N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-3-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-
THZ2
CAS: 1604810-84-5
Molecular Formula: C31H28ClN7O2
Benzamide, N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-3-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]- - Names and Identifiers
Benzamide, N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-3-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]- - Physico-chemical Properties
| Molecular Formula | C31H28ClN7O2 |
| Molar Mass | 566.05 |
| Density | 1.379±0.06 g/cm3(Predicted) |
| Solubility | DMSO: ≥ 39 mg/mL |
| pKa | 13.06±0.70(Predicted) |
| Storage Condition | -20℃ |
Benzamide, N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-3-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.767 ml | 8.833 ml | 17.666 ml |
| 5 mM | 0.353 ml | 1.767 ml | 3.533 ml |
| 10 mM | 0.177 ml | 0.883 ml | 1.767 ml |
| 5 mM | 0.035 ml | 0.177 ml | 0.353 ml |
Last Update：2024-01-02 23:10:35
Benzamide, N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-3-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]- - Reference Information
| biological activity | THZ2 is an analog of THZ1, a selective inhibitor of CDK7, and its IC50 value is 13.9 nM. THZ2 can effectively inhibit the clone formation and growth of TNBC cells, and its IC50 value is about 10 nM. |
| target | TargetValue CDK7 (Cell-free say) 13.9 nM |
| Target | Value |
| CDK7 (Cell-free assay) | 13.9 nM |
Last Update：2024-04-09 20:49:11
![Benzamide, N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-3-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-](http://res.chembk.com/assets/images/structure/HY-12280.gif)
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Spot supply
Product Name: THZ2 Visit Supplier Webpage Request for quotationCAS: 1604810-84-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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